منابع مشابه
An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome
People with Down syndrome (DS) develop Alzheimer's disease (AD) with an early age of onset. A tetranucleotide repeat, attt(5-8), in intron 7 of the amyloid precursor protein has been associated with the age of onset of AD in DS in a preliminary study. The authors examine the impact of this polymorphism in a larger cohort of individuals with DS. Adults with DS were genotyped for attt(5-8) and AP...
متن کاملPolymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome☆
It is known that Alzheimer's disease (AD) presents at an early age in people with Down syndrome (DS). The trisomy 21 in DS provides an opportunity to study the effect of duplicated genes in AD. APP and BACE2 are 2 genes located in chromosome 21 and related to AD. We looked into our cohort of 67 DS cases with dementia for the effect of BACE2 variants in age of onset of dementia. Of the 83 single...
متن کاملEvidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome
It is known that individuals with Down syndrome develop Alzheimer's disease with an early age at onset, although associated genetic risk factors have not been widely studied. We tested whether genes that increase the risk of late-onset Alzheimer's disease influence the age at onset in Down syndrome using genome-wide association data for age at onset of dementia in a small sample of individuals ...
متن کاملDementia diagnostic criteria in Down syndrome.
OBJECTIVE Dementia is a common clinical presentation among older adults with Down syndrome. The presentation of dementia in Down syndrome differs compared with typical Alzheimer's disease. The performance of manualised dementia criteria in the International Classification of Diseases (ICD)-10 and Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (DSM-IV-TR) is uncertain in ...
متن کاملEarlier age of dementia onset and shorter survival times in dementia patients with diabetes. RUNNING HEAD Dementia onset age and survival in diabetes Authors: RR Zilkens
Diabetes is a risk factor for dementia but relatively little is known about the epidemiology of the association. A retrospective population study using Western Australian hospital inpatient, mental health outpatient and death records was used to compare the age at index dementia record (proxy for onset age) and survival outcomes in dementia patients with and without preexisting diabetes (n=25,0...
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ژورنال
عنوان ژورنال: Journal of Alzheimer’s Disease & Parkinsonism
سال: 2017
ISSN: 2161-0460
DOI: 10.4172/2161-0460.1000329